STUDY OF LIVER FIBROSIS IN CHRONIC VIRAL HEPATITIS PATIENTS USING SHEAR WAVE ELASTOGRAPHY WITH ELASTOGRAPHY POINT QUANTIFICATION / Шинэ санаа Шинэ нээлт

@#BACKGROUND: Chronic viral hepatitis is the most important public health problems and main cause of liver fibrosis. Progressive hepatic fibrosis will gradually lead to liver cirrhosis, hepato-cellular carcinoma and liver failure and deaths. Study of liver fibrosis is becomes an essential issue of prevention, prognosis and radical treatment plan. The evaluation of liver fibrosis using ultrasound based-electrographic shear wave elastography (SWE) with elastography point quantification (ElastPQ) is a modern non-invasive method. This study is aimed to evaluate diagnostic value of SWE with ElastPQ feature of liver fibrosis. MATERIAL: A total of 110 patients with chronic viral (B, C and D) infection and 50 healthy controls were involved. Quantitative evaluation of LS was performed by Philips iU 22 ultrasound system with ElastPQ using convex transducer C5-1. RESULTS: In HBV patients: no fibrosis F0 score 7, mean liver stiffness was 3.1±0.28 kPa, mild liver fibrosis F1 score 26, mean LS was 4.9±0.90 kPa, F2 score 4, mean LS was 8.0±0.56 kPa, F3 score 3, mean LS was 11.0±0.83 kPa, and F4 score or liver cirrhosis 2, mean LS was 17±4.3 kPa, respectively. In patients HCV; F0 score -5, mean LS was 3.2±0,08 kPa, F1-36, mean LS was 5.0±0.94 kPa, F2 score-10, mean LS was 8.1±0.90 kPa, F3-10, mean LS was 10.9±1.03kPa, and F4 score 5, mean LS 15.9±2.8kPa, respectively. In patients with HBV, HDV; F0 score-1, liver stiffness was 3.2kPa, F1-13, mean LS was 4.9±0.72 kPa, F2 score 2, mean LS was 8.0±0.56kPa, F3 score, LS was 10.8kPa, F4 score 1, LS was 20.1kPa, respectively. CONCLUSIONS: Shear wave elastography with elastography point quantification technique is a reliable that can to detect of the earlier fibrosis stage in chronic viral hepatitis patients. ElastPQ SWE method is an optimal to monitor liver tissue stiffness in patients with chronic liver diseases.

Pharmacological Activities of a Mongolian Medicinal Plant, Malva mohileviensis Down.

Aims: To investigate the Mongolian plant M. mohileviensis Down. for the presence of possible bioactive products that could be related to the traditional use of the plant in Mongolia. Methodology: Ethanolic and water extracts of both seeds and herb were tested for antiinflammatory and DPPH scavenging activity. Polysaccharides were isolated from the seeds using sequence of chromatographic methods. The polysaccharide fraction from the cold water extract was then analyzed for the presence of monosaccharides and their type of linkages by GC and GC-MS. The effect of the polysaccharides on the complement system was then determined. Results: The ethanolic and aqueous extracts of seeds and herbs, as well as crude polysaccharides from cold and hot water extracts exhibited a significant anti-inflammatory activity in the model based on histamine-induced paw edema. Anti-inflammatory effects of all samples were high during the 3rd hour of inflammation. Moreover, the ethanolic extracts of seeds and herbs exhibited DPPH scavenging activity. Phytochemical studies of the cold water seed polysaccharide revealed the presence of an uncommon pectic type polysaccharide. Galacturonic acid (38%) and rhamnose (30%) were present as the main monosaccharides, and linkage analyses revealed that galacturonic acid was present as terminal, 14 and 13,4 linked units and rhamnose basically as 13 linked units. The complement fixation activity was appr.15 μg/ml, substantially lower than that of the standard used. The results also indicate strongly that the M. mohileviensis and M. verticillata are two different Malva species.